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focused fragment library  (Life Chemicals Inc)


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    Structured Review

    Life Chemicals Inc focused fragment library
    Focused Fragment Library, supplied by Life Chemicals Inc, used in various techniques. Bioz Stars score: 93/100, based on 28 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/focused fragment library/product/Life Chemicals Inc
    Average 93 stars, based on 28 article reviews
    focused fragment library - by Bioz Stars, 2026-04
    93/100 stars

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    BioFocus DPI kinase-focused libraries themepair fragment (tpf)
    Selection of crystallized <t>SFK</t> library compounds in the public domain ( a ) hinge binding: SFK03 compound bound to CDK2 (PDB code 2R3F); ( b ) DFG-out binding: SFK48 compound bound to p38α (PDB code 3IW8); ( c ) invariant lysine binding: SFK33 compound bound to PIM-1 (PDB code 2C3I). The hinge region is shown as a purple ribbon in each case (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this paper).
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    Image Search Results


    Selection of crystallized SFK library compounds in the public domain ( a ) hinge binding: SFK03 compound bound to CDK2 (PDB code 2R3F); ( b ) DFG-out binding: SFK48 compound bound to p38α (PDB code 3IW8); ( c ) invariant lysine binding: SFK33 compound bound to PIM-1 (PDB code 2C3I). The hinge region is shown as a purple ribbon in each case (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this paper).

    Journal: Combinatorial Chemistry & High Throughput Screening

    Article Title: The Design and Application of Target-Focused Compound Libraries

    doi: 10.2174/138620711795767802

    Figure Lengend Snippet: Selection of crystallized SFK library compounds in the public domain ( a ) hinge binding: SFK03 compound bound to CDK2 (PDB code 2R3F); ( b ) DFG-out binding: SFK48 compound bound to p38α (PDB code 3IW8); ( c ) invariant lysine binding: SFK33 compound bound to PIM-1 (PDB code 2C3I). The hinge region is shown as a purple ribbon in each case (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this paper).

    Article Snippet: Three types of kinase-focused libraries have been developed by BioFocus, namely the SoftFocus (SFK), FieldFocus (FFK) and ThemePair Fragment (TPF) libraries.

    Techniques: Selection, Binding Assay

    Example scaffolds. SFI (SoftFocus Ion channel) libraries are designed using HDRA to target the pore region of VGICs. FFI (FieldFocus Ion channel) libraries are designed to target LGICs using a ligand based design approach.

    Journal: Combinatorial Chemistry & High Throughput Screening

    Article Title: The Design and Application of Target-Focused Compound Libraries

    doi: 10.2174/138620711795767802

    Figure Lengend Snippet: Example scaffolds. SFI (SoftFocus Ion channel) libraries are designed using HDRA to target the pore region of VGICs. FFI (FieldFocus Ion channel) libraries are designed to target LGICs using a ligand based design approach.

    Article Snippet: Three types of kinase-focused libraries have been developed by BioFocus, namely the SoftFocus (SFK), FieldFocus (FFK) and ThemePair Fragment (TPF) libraries.

    Techniques: