Journal: Combinatorial Chemistry & High Throughput Screening
Article Title: The Design and Application of Target-Focused Compound Libraries
doi: 10.2174/138620711795767802
Figure Lengend Snippet: Selection of crystallized SFK library compounds in the public domain ( a ) hinge binding: SFK03 compound bound to CDK2 (PDB code 2R3F); ( b ) DFG-out binding: SFK48 compound bound to p38α (PDB code 3IW8); ( c ) invariant lysine binding: SFK33 compound bound to PIM-1 (PDB code 2C3I). The hinge region is shown as a purple ribbon in each case (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this paper).
Article Snippet: Three types of kinase-focused libraries have been developed by BioFocus, namely the SoftFocus (SFK), FieldFocus (FFK) and ThemePair Fragment (TPF) libraries.
Techniques: Selection, Binding Assay